© 2017, GENASSIST, Inc.     

By Keith S. Wexler, MBA, Maternal Fetal Medicine, Prenatal Diagnosis and Biotech/Life Sciences Consultant, GENASSIST, Inc.

Paul Wexler, M.D., F.A.C.O.G., Medical Director, GENASSIST, Inc.

Clinical Professor, Department of OB/GYN, University of Colorado Health Sciences Center

Clinical Professor, Division of Genetics/Dept. of Pediatrics, Univ. of Colorado/The Children’s Hospital

Background: Celiac Disease has been associated with decreased fertility and possible increased risk for miscarriage. 

*Gluten should be avoided by pregnant mothers with Celiac Disease.

The use of a gluten-free diet has been associated with a decrease in Intra Uterine Growth Restriction (IUGR) but definitive evidence showing a decrease in miscarriage is unproven.

Inheritance: Autosomal dominant inheritance (50%) has been described.  Autosomal recessive inheritance (25% if both parents are gene carriers) and multifactorial inheritance (2-5%)  has also been described. *It is believed that multiple genes in the individual interact with environmental factor(s) to cause a disease or defect.  Both genetic and non-genetic factors can be the cause of the disease.

When a patient has been diagnosed with Celiac Disease by biopsy, testing for HLA-DQ2 and HLA-DQ8 should also be considered. *There is an increased risk for a child with Celiac Disease

Celiac Disease symptoms can include:

  • Abdominal pain
  • Diarrhea
  • Malabsorption
  • Vitamin deficiency
  • Liver dysfunction
  • Fatigue
  • Weight loss

Consideration should be given for testing for deficiencies of folic acid, iron, calcium and Vitamins A, B6, B12, D, E and K and IgA levels. (Ory, SJ and Christine DR. Contemp OB/GYN. Reproductive Effects of Celiac Disease 2013).

Because the disease is more common than known previously, treatment is actively being pursued (Makharia, GK. Current and Emerging Therapy for Celaic Disease, Front Med 2014.